Bruce A McClane Selected Research

Clostridium enterotoxin

1/2019	Potential Therapeutic Effects of Mepacrine against Clostridium perfringens Enterotoxin in a Mouse Model of Enterotoxemia.
7/2017	The Potential Therapeutic Agent Mepacrine Protects Caco-2 Cells against Clostridium perfringens Enterotoxin Action.
10/2016	The interaction of Clostridium perfringens enterotoxin with receptor claudins.
1/2013	Human claudin-8 and -14 are receptors capable of conveying the cytotoxic effects of Clostridium perfringens enterotoxin.
12/2012	Cysteine-scanning mutagenesis supports the importance of Clostridium perfringens enterotoxin amino acids 80 to 106 for membrane insertion and pore formation.
1/2012	Use of Clostridium perfringens Enterotoxin and the Enterotoxin Receptor-Binding Domain (C-CPE) for Cancer Treatment: Opportunities and Challenges.
10/2011	Structure of the food-poisoning Clostridium perfringens enterotoxin reveals similarity to the aerolysin-like pore-forming toxins.
1/2011	Interactions between Clostridium perfringens enterotoxin and claudins.
1/2011	Identification of novel Clostridium perfringens type E strains that carry an iota toxin plasmid with a functional enterotoxin gene.
8/2008	Noncytotoxic Clostridium perfringens enterotoxin (CPE) variants localize CPE intestinal binding and demonstrate a relationship between CPE-induced cytotoxicity and enterotoxicity.

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Bruce A McClane Research Topics

Disease

35	Foodborne Diseases 01/2021 - 08/2002
20	Diarrhea 01/2021 - 04/2004
13	Gastrointestinal Diseases (Functional Gastrointestinal Disorders) 10/2021 - 01/2005
8	Infections 01/2019 - 10/2008
8	Enteritis 11/2014 - 09/2006
7	Neoplasms (Cancer) 12/2016 - 04/2007
4	Enterotoxemia 01/2019 - 01/2011
3	Intestinal Diseases (Diseases, Intestinal) 11/2014 - 01/2010
2	Necrosis 12/2019 - 08/2008
2	Gas Gangrene (Gangrene, Gas) 01/2018 - 08/2006
2	Edema (Dropsy) 10/2016 - 08/2008
1	Colic (Abdominal Cramps) 01/2021
1	Hyperkalemia 01/2019
1	Animal Diseases 01/2018
1	Enterocolitis 09/2008
1	Hemorrhage 08/2008
1	Clostridium Infections 05/2008
1	Necrotizing Enterocolitis 12/2007
1	Ovarian Epithelial Carcinoma 04/2007

Drug/Important Bio-Agent (IBA)

25	Enterotoxins (Enterotoxin)IBA 01/2021 - 08/2002
18	Anti-Bacterial Agents (Antibiotics)IBA 12/2019 - 05/2005
13	Clostridium enterotoxinIBA 01/2019 - 04/2007
8	Proteins (Proteins, Gene)FDA Link 12/2019 - 04/2004
4	Pharmaceutical PreparationsIBA 01/2019 - 01/2013
4	ClaudinsIBA 10/2016 - 01/2010
4	Clostridium perfringens theta-toxinIBA 01/2014 - 09/2006
3	Virulence Factors (Pathogenicity Factors)IBA 01/2021 - 01/2011
3	AcidsIBA 01/2016 - 05/2008
2	N-formyl-13-dihydrocarminomycin (NFD)IBA 10/2021 - 12/2018
2	Neuraminidase (Sialidase)IBA 10/2021 - 11/2014
2	TrypsinIBA 06/2015 - 10/2008
2	Claudin-4IBA 01/2008 - 04/2007
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 12/2019
1	Threonine (L-Threonine)FDA Link 12/2019
1	Serine (L-Serine)FDA Link 12/2019
1	Phosphotransferases (Kinase)IBA 12/2019
1	Quinacrine (Mepacrine)IBA 01/2019
1	AcridinesIBA 01/2019
1	Therapeutic UsesIBA 01/2019
1	Indicators and Reagents (Reagents)IBA 10/2016
1	Ion Channels (Ion Channel)IBA 10/2016
1	Clostridium perfringens epsilon-toxinIBA 10/2016
1	DNA (Deoxyribonucleic Acid)IBA 01/2016
1	EnzymesIBA 03/2014
1	Peptide Hydrolases (Proteases)FDA Link 01/2014
1	Type C PhospholipasesIBA 01/2014
1	Enterotoxin ReceptorsIBA 01/2012
1	Biological ProductsIBA 01/2012
1	Claudin-3IBA 01/2012
1	aerolysinIBA 10/2011
1	ThiamphenicolIBA 01/2011
1	Peptides (Polypeptides)IBA 01/2011
1	Tetracycline (Achromycin)FDA LinkGeneric 01/2011
1	Chloramphenicol (Chloromycetin)FDA Link 01/2011
1	NitritesIBA 07/2009
1	Trypsin InhibitorsIBA 10/2008
1	Calmodulin (Calcium-Dependent Activator Protein)IBA 01/2005
1	CalpainIBA 01/2005
1	BuffersIBA 01/2005
1	OccludinIBA 04/2004

Therapy/Procedure

5	Therapeutics 01/2019 - 01/2013
1	Aftercare (After-Treatment) 06/2015
1	Transjugular Intrahepatic Portasystemic Shunt 08/2008
1	Drug Therapy (Chemotherapy) 01/2008